Preheat the oven to 250°. In a small bowl, whisk the melted butter with the hot sauce, worcestershire sauce, ranch seasoning, garlic powder, and cayenne to combine. Pour half of the mixture into a gallon-size storage bag.
Add half of the crackers to the bag and seal it. Give the bag a gentle toss to coat in the crackers. Place the crackers on a baking sheet with a rack and repeat the process with the remaining crackers.
Bake the buttery ranch crackers for 15 minutes. Allow them to cool before serving. Store the leftovers in an airtight container in the fridge for a week.